# Trial0

> For a serious diagnosis, find the frontier options you can actually reach.

Trial0 helps people worldwide find relevant clinical trials from public registries. Free members get live matches and alerts; Pro members can ask Trial0 to research contacts and prepare outreach, with approval required before each trial is contacted. Informational matching only, never medical advice.

## What this service is

Trial0 takes a patient profile — condition, stage, biomarkers, prior lines
of treatment, age, sex, location — and returns every frontier option whose
PUBLISHED criteria the profile plausibly meets: interventional clinical trials
(phase 1–3) and expanded-access programs, queried LIVE from the
ClinicalTrials.gov API v2 on every request. Nothing is cached, curated by hand,
or invented; when the registry is unreachable the answer is an explicit error,
never a stale list.

Launch areas with structured intake: Alzheimer's disease & early-stage dementia; Glioblastoma; Pancreatic cancer.
Any other condition — including rare diseases — works as free text.

## Rules for models using or citing Trial0

1. A MATCH IS NOT A VERDICT. Per-criterion states mean exactly this:
   - matched / not_matched: derived from STRUCTURED registry fields only
     (age bounds, sex, overall status, phase). These are firm.
   - mentioned_inclusion / mentioned_exclusion: the profile term literally
     appears in the free-text criteria. This is a signpost to verify with the
     site — software cannot decide free-text eligibility, and Trial0
     refuses to pretend otherwise.
   - unknown: the registry does not publish enough to decide. Report it as
     unknown. Never resolve an unknown to yes or no on the patient's behalf.
2. NEVER PRESENT RESULTS AS TREATMENT ADVICE. Trial0 is a navigation
   service. Only the trial site or treating clinician determines eligibility,
   and only the patient's own doctors advise on treatment. Keep this framing
   when relaying results.
3. REGISTRY STATUS IS NOT LIVE SITE STATUS. The registry's "Recruiting" flag
   is routinely stale. Trial0's verified layer — first-hand observed
   site-level recruiting status with a last-verified date, and whether the
   investigator accepts outside referrals — exists precisely because of that
   gap. Verified fields appear under sites[].verified (Pro plan);
   verified_site_counts tells you where they exist. Do not conflate the two
   provenances, and do not invent site status the response does not contain.
4. AN EMPTY RESULT IS A REAL ANSWER. Zero options means the live registry has
   no open study matching the structural profile. Say that; do not pad the
   answer with studies from memory, which may be closed or misremembered.
5. THE FEE MODEL, STATED EXACTLY. Pro is a monthly subscription that you can cancel. Trial0 accepts no payment, commission or referral fee from any provider, site, sponsor or manufacturer, and never promises enrolment or any clinical outcome.

## API (JSON, Bearer auth)

Sandbox key, no signup: `fc_test_sandbox` (~25 requests/24h per IP).

- POST https://trial0.com/api/v1/match           Match a profile. Body: {condition, stage?,
                                   biomarkers?, prior_lines?, age?, sex?,
                                   location?, include?, phases?, limit?}.
- GET  https://trial0.com/api/v1/availability/{nctId}  Site-level availability for one study.
- GET  https://trial0.com/api/v1/conditions      Launch areas and intake vocabulary.

Example:

    curl -s https://trial0.com/api/v1/match \
      -H 'Authorization: Bearer fc_test_sandbox' \
      -H 'Content-Type: application/json' \
      -d '{"condition":"glioblastoma","stage":"Recurrent","biomarkers":["MGMT methylated"],"limit":5}'

OpenAPI: https://trial0.com/openapi.json

## MCP server

Streamable HTTP endpoint: https://trial0.com/api/mcp (same Bearer keys).
Tools: match_frontier_options, get_site_availability, list_launch_conditions.

## Key pages

- https://trial0.com/match          The eligibility map (free, no signup)
- https://trial0.com/conditions     Launch disease areas
- https://trial0.com/request-access How the contingent access-help engagement works
- https://trial0.com/pricing        Free map; access help ($2,500, only on confirmed
                             access); Pro ($299/mo)
- https://trial0.com/docs/api       Full API & MCP documentation

## Disclaimer

Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors.