Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions

Summary

This clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intra- and post-operative microdialysis during neurosurgery for central nervous system malignancies. A biomarker is a measurable indicator of the severity or presence of disease state. Information collected in this study may help doctors develop new strategies to better diagnose, monitor, and treat brain tumors.

Interventions

• Microdialysis · PROCEDURE

  Undergo microdialysis

• Magnetic Resonance Imaging · PROCEDURE

  Undergo MRI

• Computed Tomography · PROCEDURE

  Undergo CT

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Age \>= 18 years
* Diagnosis of the following, based on clinical and radiographic evidence:

  * Any glioma
  * Metastatic brain tumor of any primary origin
  * Epileptic focus requiring surgical resection
* Planned neurosurgical procedure for purposes of biopsy or resection of suspected or previously diagnosed brain tumor (primary or metastatic) or epileptic focus as part of routine clinical care
* Willing to undergo neurosurgical resection or biopsy at Mayo Clinic \[Rochester, Minnesota (MN)\]
* For patients with gliomas recruited for post-operative microdialysis, willingness to stay in the hospital through post-operative day (POD) 3-5 (timing per physician and patient's shared decision making)
* Ability to understand and the willingness to sign a written informed consent document
* Enrollment into the Biobank study (IRB#12-003458)

Exclusion Criteria:

* Vulnerable populations: pregnant women, prisoners or the mentally handicapped
* Patients who are not appropriate candidates for surgery due to current or past medical history or uncontrolled concurrent illness

Sites (1)

• Mayo Clinic in Rochester, Rochester, Minnesota · RECRUITING