Conditions · Glioblastoma
Glioblastoma frontier treatment options
Glioblastoma trials split sharply by newly-diagnosed versus recurrent disease and by MGMT/IDH status. Expanded-access routes exist for several device and agent programs.
Open options now (543 open studies; showing 30)
- TRIALPHASE1 / PHASE2RECRUITING
A Phase 2 Study of HX301 in Patients with High-grade Giloma
HX301+/Temozolomide — 1 site
- TRIALPHASE1ENROLLING_BY_INVITATION
Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma
Nivolumab · Azacitidine (AZA) · lumbar puncture — 1 site
- TRIALPHASE2RECRUITING
Prophylactic Regimen With Intrathecal Thiotepa in SVZ-positive or Meningeal-risk Glioblastoma
Maximal surgical resection · Concomitant Chemoradiotherapy (Stupp backbone) · Preventive Intrathecal Thiotepa — 1 site
- TRIALNANOT_YET_RECRUITING
Feasibility of ORGAnoids in Routine Clinical Practice for Molecular Analysis of the GLIOvascular Niche in Patients With Primary Brain Tumors.
Ex-vivo organoid culture — 3 sites
- TRIALPHASE3RECRUITING
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
Bevacizumab · Microbubble · Low-Intensity Focused Ultrasound — 2 sites
- TRIALPHASE1 / PHASE2RECRUITING
Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma
Pembrolizumab · Stereotactic Radiation Therapy · Surgical Resection — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma
Debio 0123 · Temozolomide · Radiotherapy — 16 sites
- EXPANDED ACCESSAVAILABLE
Glioblastoma and Individualized Therapies
Vaccination — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas
Biospecimen Collection · Eflornithine · Lumbar Puncture — 1 site
- TRIALPHASE2RECRUITING
ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas
ACT001 — 20 sites
- TRIALEARLY_PHASE1RECRUITING
Pilot Trial for Treatment of Recurrent Glioblastoma
Afatinib · Dasatinib · Palbociclib — 1 site
- TRIALNARECRUITING
Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma
Early post-operative brain PET-MRI with 18F-DOPA and Gadolinium — 1 site
- TRIALPHASE2RECRUITING
INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
Temozolomide · Neratinib · QBS10072S — 12 sites
- TRIALPHASE1 / PHASE2RECRUITING
Biomarker-Guided Dual-Target CAR-T Cells for Advanced Solid Tumors
Autologous dual-target CAR-T cells selected from the predefined target library. · Fludarabine · Cyclophosphamide — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas
Trametinib and Nivolumab · Dabrafenib, trametinib, nivolumab — 3 sites
- TRIALPHASE1 / PHASE2RECRUITING
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
TNG456 · abemaciclib — 15 sites
- TRIALPHASE2RECRUITING
Lerapolturev (PVSRIPO) in GBM
Lerapolturev · Lomustine Pill — 1 site
- TRIALPHASE1RECRUITING
Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma
ERAS-801 · ABBV-637 · ABBV-155 — 11 sites
- TRIALPHASE1RECRUITING
Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma
NK-92/5.28.z · Ezabenlimab — 5 sites
- TRIALNARECRUITING
Low-Intensity Oscillatory Magnetic Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme (GBM) - An Exposure-time Escalation Pilot Trial
Oncomagnetic device — 6 sites
- TRIALPHASE1RECRUITING
GPC-3 CAR T CELLS FOR Recurrent GPC-3 Positive Glioblastoma
15.GPC3-CAR T cells — 1 site
- TRIALPHASE1RECRUITING
Atovaquone Combined With Radiation in Children With Malignant Brain Tumors
Atovaquone · Radiation Therapy — 2 sites
- TRIALPHASE2RECRUITING
Injection of Active Allogeneic Natural Killer Cells in Patients With Gliomas
NK cell therapy — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma
Intra-arterial Cetuximab · Intra-arterial Mannitol — 1 site
- TRIALPHASE4RECRUITING
Dabrafenib and/or Trametinib Rollover Study
dabrafenib · trametinib — 33 sites
- TRIALPHASE2NOT_YET_RECRUITING
Pharmacoscopy for Patients With Refractory Primary Brain Tumors
Pharmacoscopy 1.0 — 3 sites
- TRIALPHASE1 / PHASE2NOT_YET_RECRUITING
Effect of Cytokine-induced Killer Cells for Stage I-II Malignant Gliomas
Temozolomide · CIK
- TRIALPHASE2RECRUITING
Retifanlimab with Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma
Bevacizumab · Biospecimen Collection · Computed Tomography — 3 sites
- EXPANDED ACCESSAVAILABLE
Expanded Access to Gallium Maltolate (GaM)
Gallium Maltolate — 3 sites
- TRIALPHASE2RECRUITING
A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma
Chlorophyllin — 1 site
Live from ClinicalTrials.gov, refreshed at most hourly · registry query ↗
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Each country page filters the live registry to listed sites in that country and links to the relevant official national or regional registry for additional local discovery.
Common questions
- How does Trial0 find Glioblastoma options?
- Every list on this page is a live query of ClinicalTrials.gov (API v2) for open interventional trials and expanded-access programs, refreshed at most hourly. Nothing is hand-curated or cached beyond that window.
- Does a match mean the patient is eligible?
- No. Structured registry fields (age, sex, status, phase) give firm matched/not-matched states; free-text criteria can only be checked for mentions, which are signposts to verify with the site. Only the trial site can determine actual eligibility.
- What does the verified site data mean?
- Registry recruiting status is often stale. Trial0 separately records first-hand observations — whether a specific site is really recruiting and whether the investigator accepts outside referrals — each stamped with the date it was verified.
- What does access help cost?
- The eligibility map and new-trial alerts are free. Pro is $49/month or £49/month and covers contact research, draft preparation and approval-first outreach. Trial0 never takes a commission from a provider.
How to use this Glioblastoma trial page
This page is refreshed from live registry data and shows currently open interventional studies and expanded-access programmes. Trial records are leads, not a clinical recommendation.
Use the full matcher to add age, treatment history, biomarkers and a location. It labels published criteria honestly: a mention in free text is a prompt to verify, not a finding of eligibility.
Free alerts help you notice new registry entries. Pro can research a contact and prepare outreach, but Trial0 asks for approval before contacting each trial.
Not medical advice. Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors. Data refreshed at most every 1 hour(s).