Glioblastoma — drug options
30 open options
- TRIALPHASE1 / PHASE2RECRUITING
A Phase 2 Study of HX301 in Patients with High-grade Giloma
HX301+/Temozolomide — 1 site
- TRIALPHASE1ENROLLING_BY_INVITATION
Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma
Nivolumab · Azacitidine (AZA) · lumbar puncture — 1 site
- TRIALPHASE2RECRUITING
Prophylactic Regimen With Intrathecal Thiotepa in SVZ-positive or Meningeal-risk Glioblastoma
Maximal surgical resection · Concomitant Chemoradiotherapy (Stupp backbone) · Preventive Intrathecal Thiotepa — 1 site
- TRIALPHASE3RECRUITING
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
Bevacizumab · Microbubble · Low-Intensity Focused Ultrasound — 2 sites
- TRIALPHASE1 / PHASE2RECRUITING
Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma
Pembrolizumab · Stereotactic Radiation Therapy · Surgical Resection — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma
Debio 0123 · Temozolomide · Radiotherapy — 16 sites
- TRIALPHASE1 / PHASE2RECRUITING
Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas
Biospecimen Collection · Eflornithine · Lumbar Puncture — 1 site
- TRIALPHASE2RECRUITING
ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas
ACT001 — 20 sites
- TRIALEARLY_PHASE1RECRUITING
Pilot Trial for Treatment of Recurrent Glioblastoma
Afatinib · Dasatinib · Palbociclib — 1 site
- TRIALPHASE2RECRUITING
INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
Temozolomide · Neratinib · QBS10072S — 12 sites
- TRIALPHASE1 / PHASE2RECRUITING
Biomarker-Guided Dual-Target CAR-T Cells for Advanced Solid Tumors
Autologous dual-target CAR-T cells selected from the predefined target library. · Fludarabine · Cyclophosphamide — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas
Trametinib and Nivolumab · Dabrafenib, trametinib, nivolumab — 3 sites
- TRIALPHASE1 / PHASE2RECRUITING
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
TNG456 · abemaciclib — 15 sites
- TRIALPHASE2RECRUITING
Lerapolturev (PVSRIPO) in GBM
Lerapolturev · Lomustine Pill — 1 site
- TRIALPHASE1RECRUITING
Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma
ERAS-801 · ABBV-637 · ABBV-155 — 11 sites
- TRIALPHASE1RECRUITING
Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma
NK-92/5.28.z · Ezabenlimab — 5 sites
- TRIALPHASE1RECRUITING
Atovaquone Combined With Radiation in Children With Malignant Brain Tumors
Atovaquone · Radiation Therapy — 2 sites
- TRIALPHASE1 / PHASE2RECRUITING
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma
Intra-arterial Cetuximab · Intra-arterial Mannitol — 1 site
- TRIALPHASE4RECRUITING
Dabrafenib and/or Trametinib Rollover Study
dabrafenib · trametinib — 33 sites
- TRIALPHASE1 / PHASE2NOT_YET_RECRUITING
Effect of Cytokine-induced Killer Cells for Stage I-II Malignant Gliomas
Temozolomide · CIK
- EXPANDED ACCESSAVAILABLE
Expanded Access to Gallium Maltolate (GaM)
Gallium Maltolate — 3 sites
- TRIALPHASE2RECRUITING
A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma
Chlorophyllin — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma
TGX-007 · Valaciclovir — 2 sites
- TRIALPHASE1NOT_YET_RECRUITING
Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-Linac
MR-Linac System · Radiation Therapy · Temozolomide — 1 site
- TRIALPHASE2RECRUITING
Evaluate the Role of Anthracycline After Radio Therapy in Patients With Glioblastoma (pGBM).
Radiotherapy, Temozolomide, Doxorubicin — 1 site
- TRIALPHASE2RECRUITING
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Intra-arterial Cetuximab · Intra-arterial Mannitol · Hypofractionated re-irradiation — 1 site
- TRIALPHASE3RECRUITING
Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly Glioblastoma
Hypofractionated radiotherapy · Conventional radiotherapy · Temozolomide — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery
Near-Infrared Fluorescence Imaging · Panitumumab · Panitumumab-IRDye800 — 1 site
- TRIALPHASE2NOT_YET_RECRUITING
Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype Glioblastoma
Archive Sample Retrieval · Biospecimen Collection · Chest Radiography — 3 sites
- TRIALPHASE1 / PHASE2RECRUITING
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
Biopsy Procedure · Magnetic Resonance Imaging · Radiation Therapy — 127 sites
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