Conditions · Alzheimer's disease & early-stage dementia
Alzheimer's & early-stage dementia frontier treatment options
Anti-amyloid and anti-tau programs, and most disease-modifying trials, publish narrow windows — typically MCI to mild stage with biomarker confirmation. The map shows which published windows a profile plausibly fits.
Open options now (1154 open studies; showing 30)
- TRIALNANOT_YET_RECRUITING
Making Connections Thru Music
Volunteer Led Making Connections Thru Music · Staff Led Making Connections Thru Music — 1 site
- TRIALNANOT_YET_RECRUITING
Ultrasonic Debris Clearance to Promote Brain Resilience
Ultrasonic Debris Clearance · sham — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
Sense4Safety Intervention
Sense4Safety — 1 site
- TRIALNARECRUITING
Influence of Oxidative Stress and Nutrition Biomarkers on the Cognitive Decline Evolution in Alzheimer Disease
Malnutrition screening and perioperative nutritional support — 1 site
- TRIALNARECRUITING
Evaluation of a Mobile App Program for Coping With Cancer
Tools for Coping with Cancer Calm Health mobile app program — 1 site
- TRIALPHASE1RECRUITING
Safety of a Strategy Combining Etanercept Administration With Repeated Contrast Ultrasound in Patients With Alzheimer's Disease
etanercept and repeated contrast ultrasound — 1 site
- TRIALPHASE2RECRUITING
A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia
ITI-1284 · Placebo — 70 sites
- TRIALNANOT_YET_RECRUITING
Mindfulness-Enhanced Dual-Task Training in PD-MCI
Cognitive-Motor Dual-Task Training · Mindfulness Training · Single-task Training — 1 site
- TRIALNARECRUITING
EARLY-COGN^3 - Smart Digital Solutions for EARLY Treatment of COGnitive Disability: a Neuropsychological, Neurophysiological and Neurobiological Perspective in Chronic Neurological Diseases - PNRR-MCNT2-2023-12377069
RICORDO-DTx · Home-based unstructured cognitive stimulation — 3 sites
- TRIALPHASE3NOT_YET_RECRUITING
A Prospective Multicenter RCT Study of Deep Jugular Lymphovenous Anastomosis in the Treatment of Alzheimer's Disease
Deep cervical lymphatic-venous anastomosis · Donepezil drug treatment
- TRIALNANOT_YET_RECRUITING
VR-based Multi-dimensional Intervention on Cognitive Function, With AI-agents
VR-based multi-dimensional intervention
- TRIALNARECRUITING
Case-Finding for Neurocognitive Disorders in Pavia
Case-finding for Neurocognitive Disorders — 1 site
- TRIALNANOT_YET_RECRUITING
Adaptation and Normalization of a Verbal Episodic Memory Test in French Sign Language
Questionnaire and Physical Exam
- TRIALNANOT_YET_RECRUITING
Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 2
Project 2, Phase 2: Intelligent Adaptive System — 3 sites
- TRIALPHASE2RECRUITING
DORA and LP in Alzheimer's Disease Biomarkers
Lemborexant 10 mg · Lemborexant 20mg · Placebo — 1 site
- TRIALNANOT_YET_RECRUITING
Virtual Reality Cognitive Training for Older Adults With Mild Cognitive Impairment
fi-VR Cognitive Training · Traditional Cognitive Training
- TRIALNANOT_YET_RECRUITING
Dementia and Storytelling in Vietnam
Storytelling intervention · Basic information — 1 site
- TRIALNANOT_YET_RECRUITING
Personalized Medicine in the Elderly With Vision Impairment and Mild Cognitive Impairment
nLIFE EyeFitness — 1 site
- TRIALNARECRUITING
TMS for Cognitive Decline in Aging and Preclinical AD
Active rTMS · Sham rTMS — 1 site
- TRIALNARECRUITING
Neurologic Stem Cell Treatment Study
Intravenous and Intranasal BMSC — 3 sites
- TRIALNAENROLLING_BY_INVITATION
Oral Motor and Cognitive Dual-Task Training (OMCDT) Program for Improving Oral and Cognitive Functions Among People With Oral Frailty
Oral Motor and Cognitive Dual-Task Training (OMCDT) · Oral motor exercise — 1 site
- TRIALPHASE3RECRUITING
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
Xanomeline/Trospium Chloride Capsule · Xanomeline Enteric Capsule · Placebo — 159 sites
- TRIALNARECRUITING
MIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's Disease
high-resolution diffusion MRI — 1 site
- TRIALNARECRUITING
Observation of Inhalation of CXMCI-01 Essential Oil on Patients With Mild Cognitive Impairment
Experimental Group - 100% CXMCI-01 Essential Oil · Control Group - 0.1% CXMCI-01 Essential Oil (placebo) — 2 sites
- TRIALNARECRUITING
Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
5 Sessions of Split-belt Treadmill-based Locomotor Adaptation — 1 site
- TRIALNAENROLLING_BY_INVITATION
Effects of Transcranial Temporal Interference Stimulation on Cognitive Function in Mild Cognitive Impairment
Active Temporal Interference Stimulation (TIS) · Placebo / Sham TIS — 1 site
- TRIALPHASE2ENROLLING_BY_INVITATION
A Pilot Study to Examine the Effect of Egb761 on Plasma Biomarker Levels and on Cognitive Function in Patients With MCI
Ginkgo Biloba Extract 761 — 1 site
- TRIALPHASE1 / PHASE2RECRUITING
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
Placebo (Study Part 1a) · ACI-24.060 at Dose A in Study Part 1a · ACI-24.060 at Dose B in Study Part 1a — 26 sites
- TRIALNANOT_YET_RECRUITING
Silkworm Pupa Powder Improves Alzheimer's Disease
Silkworm pupa powder — 1 site
- TRIALNANOT_YET_RECRUITING
Mindfulness-Based Cognitive Therapy Vs. the Health Enhancement Program for Chronic Pain and Early Cognitive Decline; The Feeling of Being Pilot RCT
Feeling of Being · Health Enhancement Program — 1 site
Live from ClinicalTrials.gov, refreshed at most hourly · registry query ↗
Narrow by phase or treatment type
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By country
Each country page filters the live registry to listed sites in that country and links to the relevant official national or regional registry for additional local discovery.
Common questions
- How does Trial0 find Alzheimer's disease & early-stage dementia options?
- Every list on this page is a live query of ClinicalTrials.gov (API v2) for open interventional trials and expanded-access programs, refreshed at most hourly. Nothing is hand-curated or cached beyond that window.
- Does a match mean the patient is eligible?
- No. Structured registry fields (age, sex, status, phase) give firm matched/not-matched states; free-text criteria can only be checked for mentions, which are signposts to verify with the site. Only the trial site can determine actual eligibility.
- What does the verified site data mean?
- Registry recruiting status is often stale. Trial0 separately records first-hand observations — whether a specific site is really recruiting and whether the investigator accepts outside referrals — each stamped with the date it was verified.
- What does access help cost?
- The eligibility map and new-trial alerts are free. Pro is $49/month or £49/month and covers contact research, draft preparation and approval-first outreach. Trial0 never takes a commission from a provider.
How to use this Alzheimer's disease & early-stage dementia trial page
This page is refreshed from live registry data and shows currently open interventional studies and expanded-access programmes. Trial records are leads, not a clinical recommendation.
Use the full matcher to add age, treatment history, biomarkers and a location. It labels published criteria honestly: a mention in free text is a prompt to verify, not a finding of eligibility.
Free alerts help you notice new registry entries. Pro can research a contact and prepare outreach, but Trial0 asks for approval before contacting each trial.
Not medical advice. Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors. Data refreshed at most every 1 hour(s).