The Impact of Resistance ExerciSe on Muscle Mass in GlioblaSToma Survivors

Summary

Glioblastoma patients are confronted with a debilitating disease associated with a low survival rate and poor quality of life. The goal of this study will be to reach a largely underrepresented population in the exercise literature and explore the role of a tailored circuit-based resistance training program on functional fitness (i.e., ability to carry out tasks of daily living) and associated health outcomes (e.g., quality of life) for GBM patients on active treatment.

Interventions

• Circuit-based resistance exercise (CRT) · BEHAVIORAL

  CRT is a common training method used to foster aerobic fitness, muscular endurance and strength, as well as neuromuscular adaptations in one workout. CRT is comprised of several sets of different exercises with little rest in between each set.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* histologically confirmed diagnosis of either primary or secondary GBM
* received any dose of DEX
* Karnofsky Performance Status (KPS) \>70
* English fluency
* physician approval
* willingness to travel to Halifax to participate.

Exclusion Criteria:

* unstable or symptomatic cardiac or pulmonary disease, injury or co-morbid disease that precludes ability to safely exercise
* significant cognitive limitations
* uncontrolled seizures associated with impaired awareness

Sites (1)

• QEII Health Sciences Centre, Halifax, Nova Scotia, Canada