A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Summary

The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatment for adults with advanced solid tumors. The study will be conducted in two parts: PF-07799544 as a single agent (Phase 1a) and PF-07799544 in combination with another study medicine called PF-07799933 (Phase 1b). Phase 1a is no longer open for enrollment. In Phase1b (noted as "this study"), we are seeking participants who have: * a solid tumor which is metastatic or recurrent (excluding colorectal cancer) * tumor with the mutation (abnormal gene) called "BRAF V600" * received required prior treatment for cancer per cohort assigned. All participants in this study will receive both study medicines. Both study medicines are tablets that are taken by mouth at home twice a day. Participants will receive study medicines until their cancer is no longer responding, unacceptable side effects, or 2 years. Participants may continue to receive study therapy beyond 2 years. We will examine the experiences of people receiving the study medicines. This will help us determine if the study medicines are safe and effective.

Interventions

• PF-07799544 · DRUG

  Tablet

• PF-07799933 · DRUG

  Tablet

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Phase 1b Inclusion Criteria:

* Diagnosis of advanced/metastatic solid tumor (excluding colorectal cancer)
* Measurable disease by RECIST version 1.1
* Evidence of a BRAF V600 mutation
* Prior therapy per tumor cohort
* Adequate organ function per protocol

Phase 1b Exclusion Criteria:

* Other active malignancy within 3 years
* Presence of leptomeningeal disease
* History or current evidence of retinal vein occlusion (RVO) or history of retinal degenerative disease
* Concurrent neuromuscular disorder associated with elevated creatine kinase (CK)
* Active gastrointestinal disease as defined per protocol
* History of interstitial lung disease as defined per protocol

Sites (83)

• The Kirklin Clinic of UAB Hospital, Birmingham, Alabama · RECRUITING
• The University of Alabama at Birmingham, Birmingham, Alabama · RECRUITING
• University of Alabama at Birmingham - Phase I Clinical Trials Unit, Birmingham, Alabama · RECRUITING
• Highlands Oncology Group, PA, Fayetteville, Arkansas · RECRUITING
• Highlands Oncology Group, PA, Rogers, Arkansas · RECRUITING
• Highlands Oncology Group, PA, Springdale, Arkansas · RECRUITING
• The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate, Los Angeles, California · RECRUITING
• Keck Hospital of USC, Los Angeles, California · NOT_YET_RECRUITING
• Los Angeles General Medical Center, Los Angeles, California · NOT_YET_RECRUITING
• USC/Norris Comprehensive Cancer Center, Los Angeles, California · NOT_YET_RECRUITING
• Keck Medical Center of USC Pasadena, Pasadena, California · NOT_YET_RECRUITING
• UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California · RECRUITING
• UCSF Helen Diller Medical Center at Parnassus Heights, San Francisco, California · RECRUITING
• UCSF Medical Center, Investigational Pharmacy, San Francisco, California · RECRUITING
• The Angeles Clinic and Research Institue, A Cedars-Sinai Affiliate (Emergency Back-up only), Santa Monica, California · RECRUITING
• Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center, Tampa, Florida · RECRUITING
• Moffitt Cancer Center, Tampa, Florida · RECRUITING
• Moffitt McKinley Hospital, Tampa, Florida · RECRUITING
• Ochsner Clinic Foundation, New Orleans, Louisiana · NOT_YET_RECRUITING
• Massachusetts General Hospital, Boston, Massachusetts · RECRUITING
• Ophthalmic Consultants of Boston Inc (OCB), Boston, Massachusetts · RECRUITING
• Brigham and Women's Hospital, Boston, Massachusetts · RECRUITING
• Dana-Farber Cancer Institute, Boston, Massachusetts · RECRUITING
• Mass General Waltham, Waltham, Massachusetts · RECRUITING
• Brigitte Harris Cancer Pavilion, Detroit, Michigan · RECRUITING
• Henry Ford Hospital, Detroit, Michigan · RECRUITING
• HealthPartners Frauenshuh Cancer Center, Saint Louis Park, Minnesota · NOT_YET_RECRUITING
• Methodist Hospital Inpatient Pharmacy, Saint Louis Park, Minnesota · NOT_YET_RECRUITING
• HealthPartners Cancer Center at regions Hospital, Saint Paul, Minnesota · NOT_YET_RECRUITING
• Regions Hospital Pharmacy, Saint Paul, Minnesota · NOT_YET_RECRUITING
• MSK Basking Ridge., Basking Ridge, New Jersey · RECRUITING
• MSK Monmouth., Middletown, New Jersey · RECRUITING
• MSK Bergen., Montvale, New Jersey · RECRUITING
• Optum Medical Care, PC, Brewster, New York · NOT_YET_RECRUITING
• MSK Commack., Commack, New York · RECRUITING
• MSK Westchester., Harrison, New York · RECRUITING
• Optum Medical Care, PC, Mount Kisco, New York · NOT_YET_RECRUITING
• Laura & Isaac Perlmutter Cancer Center - NYU ACC, New York, New York · RECRUITING
• Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York · RECRUITING
• NYU Langone Faculty Group Practice, New York, New York · RECRUITING
• NYU Langone Medical Center (Tisch Hospital), New York, New York · RECRUITING
• Memorial Sloan Kettering Cancer Center 53rd street., New York, New York · RECRUITING
• Columbia University Irving Medical Center, New York, New York · RECRUITING
• Columbia University Medical Center - Neurological Institute of New York, New York, New York · RECRUITING
• CUIMC Research Pharmacy, New York, New York · RECRUITING
• Memorial Sloan Kettering Cancer Center - Main Campus, New York, New York · RECRUITING
• MSK Nassau., Uniondale, New York · RECRUITING
• Cleveland Clinic Taussig Cancer Center Investigational Pharmacy, Cleveland, Ohio · RECRUITING
• Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio · RECRUITING
• Providence Cancer Institute Franz Clinic, Portland, Oregon · RECRUITING
• Providence Portland Medical Center, Portland, Oregon · RECRUITING
• UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania · NOT_YET_RECRUITING
• SCRI Oncology Partners, Nashville, Tennessee · RECRUITING
• University of Texas MD Anderson Cancer Center, Houston, Texas · RECRUITING
• Fred Hutchinson Cancer Center, Seattle, Washington · RECRUITING
• University of Washington Medical Center, Seattle, Washington · RECRUITING
• University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin · RECRUITING
• University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin · RECRUITING
• Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia · RECRUITING
• The Alfred Hospital, Melbourne, Victoria, Australia · RECRUITING
• Royal Melbourne Hospital, Parkville, Victoria, Australia · RECRUITING
• Hospital Nossa Senhora da Conceição, Porto Alegre, Rio Grande do Sul, Brazil · RECRUITING
• ANIMI - Unidade de Tratamento Oncologico, Lages, Santa Catarina, Brazil · RECRUITING
• Centro de Oncologia - CEON+ - Unidade São Caetano do Sul, São Caetano do Sul, Brazil · RECRUITING
• IBCC - Núcleo de Pesquisa e Ensino, São Paulo, Brazil · RECRUITING
• Cross Cancer Institute, Edmonton, Alberta, Canada · RECRUITING
• Alberta Health Services and The Governors of The University of Alberta, Edmonton, Alberta, Canada · RECRUITING
• The Ottawa Hospital - General Campus, Ottawa, Ontario, Canada · RECRUITING
• Sunnybrook Research Institute, Toronto, Ontario, Canada · RECRUITING
• Princess Margaret Cancer Centre, Toronto, Ontario, Canada · RECRUITING
• Jewish General Hospital, Montreal, Quebec, Canada · RECRUITING
• McGill University Health Centre, Montreal, Quebec, Canada · RECRUITING
• Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Québec, Quebec, Canada · RECRUITING
• Fujian Cancer Hospital, Fuzhou, Fujian, China · RECRUITING
• Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China · RECRUITING
• The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China · RECRUITING
• Rabin Medical Center, Petah Tikva, Central District, Israel · RECRUITING
• Sheba Medical Center, Ramat Gan, Central District, Israel · RECRUITING
• Hadassah Medical Center, Jerusalem, Jerusalem, Israel · NOT_YET_RECRUITING
• Soroka Medical Center, Beersheba, Southern District, Israel · RECRUITING
• Sourasky Medical Center, Tel Aviv, TELL ABĪB, Israel · RECRUITING
• National Cancer Center Hospital East, Kashiwa, Chiba, Japan · RECRUITING
• Kansai Medical University Hospital, Hirakata, Osaka, Japan · RECRUITING