Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study

Summary

The purpose of this study is to generate preliminary data on the benefit of computerized cognitive training and Tai Chi- Qi Gong training in participants with Early-Onset Alzheimer's Disease. It is hypothesized that participants in the experimental training condition will perform better on outcomes related to cognition, functioning, and mood at follow-up compared to participants assigned to the active control condition.

Interventions

• Cognitive Training · DEVICE

  Participants will be asked to complete approximately 45 minutes of training, 4-5 sessions per week for 14 weeks (corresponding to approximately 40 hours of training total). Training will be completed via BrainHQ, a mobile application that, as used in this study, meets the FDA's definition of a medical device.

• Tai Chi- Qi Gong · BEHAVIORAL

  Participants will be asked to complete 14 hours of training total (in 30-minute sessions, 2 days per week for 14 weeks).

• Brain Games · DEVICE

  Participants will be asked to complete 40 hours of training total (in 45-minute sessions, 4 to 5 days per week for 14 weeks). Training will be completed via BrainHQ, a mobile application that, as used in this study, meets the FDA's definition of a medical device.

• Stretching · BEHAVIORAL

  Participants will be asked to engage in stretching exercises twice per week, for approximately 20-30 minutes per session. This will total 14 hours over the course of 14 weeks.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Enrolled in the Longitudinal Early-Onset AD Study (LEADS) parent study, and being classified via LEADS consensus criteria as having amyloid-positive Early Onset Alzheimer's Disease
* Aged 40-64 years at the time of enrollment into LEADS
* Fluent in English
* In good general health and absent another neurological disorder
* Have a knowledgeable informant.
* Have had a Clinical Dementia Rating scale of 0.5 to 1.0 at the time of enrollment into LEADS
* Have sufficient vision, hearing, comprehension, and manual dexterity to participate in the testing and training program

Exclusion Criteria:

• Have access to the internet (e.g., home, family, public library, etc.) for less than 4 hours per week

Sites (1)

• Indiana University, Indianapolis, Indiana · RECRUITING