A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI

Summary

This clinical trial is being conducted to see if brain stimulation and brain training together improves cognitive functioning and mood in older adults diagnosed with Mild Cognitive Impairment (MCI). Brain stimulation will be done using repetitive Transcranial Magnetic Stimulation (rTMS). Brain training will be done using immersive virtual reality cognitive training (iVCT) program. The goals of this clinical trail are as follows: * Examine if rTMS+iVCT intervention can improve and sustain objective cognitive functioning in individuals with MCI more than control or rTMS only groups * Examine if rTMS+iVCT intervention improves participants mental health symptoms, functional abilities, and quality of life more than control or rTMS only groups * Examine the impact of rTMS+iVCT intervention on caregiver burden. Eligible participants will be assigned to a standard treatment (no intervention control) group, rTMS only group of rTMS+iVCT group. All participants will undergo baseline assessment to evaluate their cognitive, emotional, and functional abilities. Those in the rTMS only group will receive rTMS treatments for five days per week for two weeks (total of ten sessions). Those in the rTMS+iVCT group will receive rTMS treatment followed by iVCT training for five days a week for two weeks (total of ten sessions). All participants will then repeat testing 2 weeks and three months after baseline testing to assess for possible treatment related changes and lasting effects.

Interventions

• rTMS · DEVICE

  Transcranial Magnetic Stimulation

• rTMS+iVCT · DEVICE

  Transcranial Magnetic Stimulation and immersive virtual reality

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* age 55 and over
* previous diagnosis of Mild Cognitive Impairment
* Score of 18 or over on the MoCA during pre-screening procedures.

Exclusion Criteria:

* below 55 years old
* Do not pass the TMS Adult Safety Screening
* Taking medications known to increase risk of seizure
* Taking ototoxic medications
* Those with implanted device
* History of bipolar disorder
* History of Tourette's syndrome or presence of motor tics
* History of seizures/ seizures in first degree relatives
* History of stroke, aneurysm, or cranial neurosurgery
* Current alcohol related disorder needing medical treatment
* History of abnormal electroencephalogram (EEG)
* History of motion sickness, nausea, vomiting, seizures, or migraine
* Significant balance/gait impairments/history of falls
* History of hyperacusis or photophobia

Sites (1)

• Central Arkansas VA Healthcare system, Little Rock, Arkansas · RECRUITING