Clinical trial · NCT06585787 · RECRUITING · PHASE3

A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Summary

The purpose of this study is to evaluate the safety and efficacy of KarXT in adult participants with mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD.

Interventions

KarXT · DRUG
Specified dose on specified days
Placebo · DRUG
Specified dose on specified days

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria

* Patients who are 55 to 90 years of age, inclusive, at the time of Screening (Visit 1).
* Patients who are diagnosed with AD based on the 2024 revised criteria for diagnosis and staging of AD: Alzheimer's Association Workgroup.
* Patient must have a magnetic resonance imaging (MRI) or computed tomography (CT) scan of the brain (completed within the past 5 years) taken during or subsequent to the onset of dementia to rule out other central nervous system (CNS) disease that could account for the dementia syndrome, eg, major stroke, neoplasm, subdural hematoma.
* Patient must have a history of psychotic symptoms (meeting International Psychogeriatric Association criteria) for at least 2 months prior to Screening (Visit 1) (participants may or may not have symptoms of agitation).

Exclusion Criteria

\- Patients will not be able to participate if they have:

i) Psychotic symptoms that are primarily attributable to a condition other than the AD causing the dementia, eg, schizophrenia, schizoaffective disorder, delusional disorder, or mood disorder with psychotic features.

ii) History of major depressive episode with psychotic features during the 12 months prior to Screening, or history of bipolar disorder, schizophrenia, or schizoaffective disorder.

iii) Patients are not able to participate if they have certain safety concerns, including certain laboratory test irregularities.

\* Other protocol-defined Inclusion/Exclusion criteria apply.

Sites (292)

Local Institution - 1227, Chandler, Arizona · COMPLETED
Gilbert Neurology Partners - PLLC - Avacare, Gilbert, Arizona · RECRUITING
Banner Alzheimer's Institute, Phoenix, Arizona · RECRUITING
Local Institution - 1220, Scottsdale, Arizona · COMPLETED
Advanced Research Center, Inc., Anaheim, California · RECRUITING
Inland Psychiatric Medical Group (IPMG)-Chino, Chino, California · RECRUITING
Local Institution - 1230, Long Beach, California · COMPLETED
USC - The Memory and Aging Center (MAC) - Alzheimer Disease Research Center (ADRC), Los Angeles, California · RECRUITING
Local Institution - 1219, Los Angeles, California · WITHDRAWN
Local Institution - 1001, Orange, California · COMPLETED
Local Institution - 1228, Orange, California · COMPLETED
Local Institution - 1043, Pasadena, California · ACTIVE_NOT_RECRUITING
Local Institution - 1213, Rancho Cucamonga, California · ACTIVE_NOT_RECRUITING
University of Connecticut Health Center, Farmington, Connecticut · RECRUITING
Local Institution - 1225, Atlantis, Florida · COMPLETED
Envision Trials LLC, Bonita Springs, Florida · RECRUITING
Local Institution - 1138, Cutler Bay, Florida · ACTIVE_NOT_RECRUITING
Arrow Clinical Trials, Daytona Beach, Florida · RECRUITING
Local Institution - 1224, Deerfield Beach, Florida · COMPLETED
Local Institution - 1164, Doral, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1264, Gulf Breeze, Florida · NOT_YET_RECRUITING
Local Institution - 1120, Hialeah, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1237, Hialeah, Florida · COMPLETED
Local Institution - 1229, Homestead, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1040, Lady Lake, Florida · COMPLETED
Local Institution - 1159, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1021, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1125, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1236, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1115, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1010, Miami, Florida · COMPLETED
Local Institution - 1143, Miami, Florida · COMPLETED
Local Institution - 1113, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1129, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1150, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1006, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1111, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1158, Miami, Florida · COMPLETED
Local Institution - 1235, Miami, Florida · COMPLETED
Local Institution - 1147, Miami, Florida · COMPLETED
Local Institution - 1234, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1105, Miami, Florida · COMPLETED
Local Institution - 1157, Miami, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1126, Miami Gardens, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1209, Miami Lakes, Florida · COMPLETED
Local Institution - 1118, Miami Lakes, Florida · ACTIVE_NOT_RECRUITING
Aqualane Clinical Research, Naples, Florida · RECRUITING
Sensible HealthCare, LLC, Ocoee, Florida · RECRUITING
Charter Research Orlando, Orlando, Florida · RECRUITING
Nova Psychiatry, Orlando, Florida · RECRUITING
Combined Research Orlando Phase I-IV LLC, Orlando, Florida · RECRUITING
Local Institution - 1204, Ormond Beach, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1205, Port Orange, Florida · ACTIVE_NOT_RECRUITING
Local Institution - 1133, Sweetwater, Florida · COMPLETED
Local Institution - 1123, Tampa, Florida · ACTIVE_NOT_RECRUITING
Guardian Angel Research, Tampa, Florida · RECRUITING
Interventional Psychiatry of Tampa Bay, Tampa, Florida · RECRUITING
Charter Research, The Villages, Florida · RECRUITING
Local Institution - 1233, Wellington, Florida · WITHDRAWN
Premiere Research Institute at Palm Beach Neurology, PA, West Palm Beach, Florida · RECRUITING
Agile Clinical Research Trials, LLC, Atlanta, Georgia · RECRUITING
McLean Hospital, Belmont, Massachusetts · RECRUITING
Tufts Medical Center - 800 Washington St - PPDS, Boston, Massachusetts · RECRUITING
Boston Neuro Research Center, North Dartmouth, Massachusetts · RECRUITING
Local Institution - 1250, South Dartmouth, Massachusetts · COMPLETED
Elixia Health - Springfield - Elixia - PPDS, Springfield, Massachusetts · RECRUITING
Neurobehavioral Medicine Group (NBMG), Bloomfield Township, Michigan · RECRUITING
Precise Research Centers, Flowood, Mississippi · RECRUITING
Tekton Research, LLC - Saint Louis Psychiatry - PPDS, St Louis, Missouri · RECRUITING
Advanced Memory Research Institute - CenExel - PPDS, Toms River, New Jersey · RECRUITING
Local Institution - 1232, Toms River, New Jersey · ACTIVE_NOT_RECRUITING
Mid Hudson Medical Research PLLC, New Windsor, New York · RECRUITING
Local Institution - 1231, Syracuse, New York · WITHDRAWN
SUNY Upstate Medical University, Syracuse, New York · RECRUITING
Five Towns Neurology, PC, Woodmere, New York · RECRUITING
Triad Clinical Trials - 515 College Rd, Greensboro, North Carolina · RECRUITING
AMC Research, LLC - Flourish - PPDS, Matthews, North Carolina · RECRUITING
Local Institution - 5005, Morehead City, North Carolina · WITHDRAWN
West Clinical Research, Morehead City, North Carolina · RECRUITING
Local Institution - 1252, Shelby, North Carolina · WITHDRAWN
Ohio State University, Columbus, Ohio · RECRUITING
Local Institution - 1258, Dayton, Ohio · NOT_YET_RECRUITING
Insight Clinical Trials LLC - Independence, Independence, Ohio · RECRUITING
The Rivus Wellness & Research Institute, Oklahoma City, Oklahoma · RECRUITING
Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital, Providence, Rhode Island · RECRUITING
Vanderbilt Psychiatric Hospital, Nashville, Tennessee · RECRUITING
Local Institution - 1263, Austin, Texas · NOT_YET_RECRUITING
Local Institution - 1260, Dallas, Texas · NOT_YET_RECRUITING
Epic Medical Research LLC - DeSoto, DeSoto, Texas · RECRUITING
Advanced Neuro Research Center - El Paso, El Paso, Texas · RECRUITING
Local Institution - 1262, Fort Worth, Texas · NOT_YET_RECRUITING
Local Institution - 1261, Houston, Texas · NOT_YET_RECRUITING
University Hills Clinical Research - 102 Decker Ct, Irving, Texas · RECRUITING
Local Institution - 1238, Plano, Texas · COMPLETED
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, San Antonio, Texas · RECRUITING
Local Institution - 1134, Stafford, Texas · COMPLETED
Conquest Research, LLC - Virginia - Vienna, Vienna, Virginia · RECRUITING
Northwest Clinical Research Center, Bellevue, Washington · RECRUITING
Local Institution - 1254, Kirkland, Washington · WITHDRAWN
CINME S.A. - Centro de Investigaciones Metabólicas - Viamonte 2213/2215, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina · RECRUITING
Centro Neurobiológico y de Estrés Traumático - CENydET S.R.L., Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina · RECRUITING
Fundación para el Estudio y Tratamiento de Enfermedades mentales- FETEM, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina · RECRUITING
Instituto Médico de la Fundación Estudios Clínicos, Rosario, Santa Fe Province, Argentina · RECRUITING
Hospital Italiano de Buenos Aires, Buenos Aires, Argentina · RECRUITING
Organización Médica de Investigación, Buenos Aires, Argentina · RECRUITING
Fundación Para La Lucha Contra Las Enfermedades Neurológicas de La Infancia - FLENI, Buenos Aires, Argentina · RECRUITING
Centro Especializado en Neurociencias - CEN, Córdoba, Argentina · RECRUITING
Instituto Privado Kremer, Córdoba, Argentina · RECRUITING
Local Institution - 2806, Jette, Brussels Capital, Belgium · COMPLETED
Local Institution - 2803, Roeselare, West-Vlaanderen, Belgium · COMPLETED
Local Institution - 2804, Alken, Belgium · COMPLETED
Local Institution - 2807, Bruges, Belgium · WITHDRAWN
Local Institution - 2805, Kortrijk, Belgium · COMPLETED
L2 Ip - Instituto de Pesquisas Clinicas Ltda - ME, Brasília, Federal District, Brazil · RECRUITING
CPQuali Pesquisa Clínica Sao Paulo, São Paulo, São Paulo, Brazil · RECRUITING
BR Trials - Pesquisa Clínica, São Paulo, São Paulo, Brazil · RECRUITING
Hospital Alemao Oswaldo Cruz (HAOC), São Paulo, São Paulo, Brazil · RECRUITING
Clinilive, São Paulo, São Paulo, Brazil · RECRUITING
Ruschel Medicina, Rio de Janeiro, Brazil · RECRUITING
Instituto de Psiquiatria HC FMUSP, São Paulo, Brazil · RECRUITING
Local Institution - 4506, Sofia, Sofia-Grad, Bulgaria · COMPLETED
University Multiprofile Hospital for Active Treatment Sveti Georgi EAD-66 Peshtersko Shosse blvd, Plovdiv, Bulgaria · RECRUITING
University Multiprofile Hospital For Active Treatment Kanev AD, Rousse, Bulgaria · RECRUITING
Medical Center Medika 2005 - Branch Sofia, Sofia, Bulgaria · RECRUITING
Local Institution - 4510, Sofia, Bulgaria · WITHDRAWN
China-Japan Friendship Hospital, Beijing, Beijing Municipality, China · RECRUITING
Beijing Anding Hospital Capital Medical University, Beijing, Beijing Municipality, China · RECRUITING
Beijing Hospital, Beijing, Beijing Municipality, China · RECRUITING
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing Municipality, China · RECRUITING
Local Institution - 7008, Guangzhou, Guangdong, China · WITHDRAWN
Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China · RECRUITING
Shenzhen Kangning Hospital, Shenzhen, Guangdong, China · RECRUITING
The Second Affiliated Hospital of Nanjing Medical University - Main Campus, Nanjing, Jiangsu, China · RECRUITING
Nanjing Brain Hospital, Nanjing, Jiangsu, China · RECRUITING
Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China · RECRUITING
Local Institution - 7029, Xi'an, Shan1xi, China · NOT_YET_RECRUITING
Shanghai Mental Health Center - PPDS, Shanghai, Shanghai Municipality, China · RECRUITING
Tongji Hospital of Tongji University, Shanghai, Shanghai Municipality, China · RECRUITING
Local Institution - 7026, Shanghai, Shanghai Municipality, China · NOT_YET_RECRUITING
West China Hospital Sichuan University, Chengdu, Sichuan, China · RECRUITING
Tianjin Anding Hospital(Tianjin mental Health Center), Tianjin, Tianjin Municipality, China · RECRUITING
Sir Run Run Shaw Hospital Zhejiang University School of Medicine - Qiantang Campus, Hangzhou, Zhejiang, China · RECRUITING
Zhejiang Hospital - Lingyin Campus, Hangzhou, Zhejiang, China · RECRUITING
Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China · RECRUITING
The Affiliated Kangning Hospital of Ningbo University - Zhuangshi Campus, Ningbo, Zhejiang, China · RECRUITING
Xiangya Hospital Central South University, Changsha, China · RECRUITING
First Affiliated Hospital of Kunming Medical University, Kunming, China · RECRUITING
Local Institution - 4102, Zagreb, City of Zagreb, Croatia · COMPLETED
Local Institution - 4105, Zagreb, City of Zagreb, Croatia · COMPLETED
Local Institution - 4106, Zagreb, City of Zagreb, Croatia · WITHDRAWN
Local Institution - 4101, Zagreb, City of Zagreb, Croatia · COMPLETED
Local Institution - 4104, Zagreb, City of Zagreb, Croatia · COMPLETED
Local Institution - 2510, Nice, Alpes-Maritimes, France · COMPLETED
CHRU de Tours - Hôpital Bretonneau, Tours, Indre-et-Loire, France · RECRUITING
Local Institution - 2512, Toulouse, France · WITHDRAWN
CHU de Toulouse- Gerontopole, Toulouse, France · RECRUITING
Local Institution - 2407, Böblingen, Baden-Wurttemberg, Germany · WITHDRAWN
Local Institution - 2402, Homburg, Saarland, Germany · COMPLETED
Local Institution - 2406, Berlin, Germany · WITHDRAWN
Local Institution - 2404, Erbach im Odenwald, Germany · COMPLETED
Local Institution - 2405, Frankfurt am Main, Germany · COMPLETED
Local Institution - 4803, Athens, Attica, Greece · COMPLETED
Local Institution - 4802, Chaidari, Athens, Attica, Greece · COMPLETED
Local Institution - 4810, Kalyftaki-N. Kifissia, Attica, Greece · COMPLETED
PAGNI-University General Hospital of Heraklion, Heraklion, Irakleio, Greece · RECRUITING
Local Institution - 4811, Thessaloniki, Greece · COMPLETED
Psychotech Kft., Pécs, Baranya, Hungary · RECRUITING
Local Institution - 4610, Szeged, Csongrád megye, Hungary · WITHDRAWN
Clinexpert Gyöngyös Kft., Gyöngyös, Heves County, Hungary · RECRUITING
Semmelweis Egyetem Pszichiátriai és Pszichoterápiás Klinika, Budapest, Hungary · RECRUITING
Eszak-budai Szent Janos Centrumkorhaz, Budapest, Hungary · RECRUITING
Local Institution - 1-13SNAZL0, Aurangabad, Maharashtra, India · NOT_YET_RECRUITING
Central Institute of Behavioural Sciences, Nagpur, Maharashtra, India · RECRUITING
Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, Punjab, India · RECRUITING
Jawaharlal Nehru Medical College, Ajmer, Ajmer, Rajasthan, India · RECRUITING
Asha Hospital - Hyderabad, Hyderabad, India · RECRUITING
Institute of Neurosciences Kolkata, Kolkata, India · RECRUITING
Deva Institute of Healthcare & Research (DIHR) Pvt Ltd (Deva Institute of Healthcare), Varanasi, India · RECRUITING
Local Institution - 3101, Jerusalem, Jerusalem, Israel · COMPLETED
Local Institution - 3103, Ashkelon, Tel Aviv, Israel · COMPLETED
Local Institution - 3102, Petah Tikva, Israel · COMPLETED
Local Institution - 3104, Ramat Gan, Israel · COMPLETED
Local Institution - 2325, Salerno, Campania, Italy · WITHDRAWN
Local Institution - 2322, Rome, Lazio, Italy · COMPLETED
Local Institution - 2320, Rome, Lazio, Italy · COMPLETED
IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Lombardy, Italy · RECRUITING
Local Institution - 2323, Milan, Lombardy, Italy · COMPLETED
Local Institution - 2307, Ponderano (Biella), Piedmont, Italy · COMPLETED
Local Institution - 2321, Rome, Roma, Italy · WITHDRAWN
Local Institution - 2309, Roma, Italy · COMPLETED
Local Institution - 7503, Iizuka, Fukuoka, Japan · COMPLETED
Southern TOHOKU Medical Clinic, Kōriyama, Fukushima, Japan · RECRUITING
Local Institution - 7522, Sapporo, Hokkaido, Japan · COMPLETED
Hyogo Prefectural Harima-Himeji General Medical Center, Himeji-Shi, Hyōgo, Japan · RECRUITING
Memory Clinic Toride, Toride-shi, Ibaraki, Japan · RECRUITING
Local Institution - 7514, Takamatsu, Kagawa-ken, Japan · COMPLETED
Hatano Kousei Hospital, Hadano, Kanagawa, Japan · RECRUITING
Koukan Clinic, Kawasaki-Shi, Kanagawa, Japan · RECRUITING
Local Institution - 7520, Yokohama, Kanagawa, Japan · COMPLETED
Yokohama City Minato Red Cross Hospital, Yokohama, Kanagawa, Japan · RECRUITING
Yokohama City University Hospital, Yokohama, Kanagawa, Japan · RECRUITING
National Hospital Organization Utano National Hospital, Kyoto, Kyoto, Japan · RECRUITING
Local Institution - 7506, Tsu, Mie-ken, Japan · COMPLETED
Asakayama General Hospital, Sakai, Osaka, Japan · RECRUITING
Shin-Abuyama Hospital, Takatsuki, Osaka, Japan · RECRUITING
Local Institution - 7510, Kanzaki-Gun Yoshinogari-Cho, Saga-ken, Japan · WITHDRAWN
Local Institution - 7504, Wako-Shi, Saitama, Japan · COMPLETED
Local Institution - 7512, Yoshinogawa, Tokushima, Japan · COMPLETED
Local Institution - 7518, Hachiōji, Tokyo, Japan · COMPLETED
Sangenjaya Nakamura Mental Clinic, Setagaya-Ku, Tokyo, Japan · RECRUITING
Kurumi Clinic, Setagaya-Ku, Tokyo, Japan · RECRUITING
Tokyo Metropolitan Matsuzawa Hospital, Setagaya-Ku, Tokyo, Japan · RECRUITING
Local Institution - 7515, Fukuoka, Japan · WITHDRAWN
Funairi nou clinic, Hiroshima, Japan · RECRUITING
Yuge Neuropsychiatric Hospital, Kumamoto, Japan · RECRUITING
Tsutsujimental Hospital, Tatebayashi, Japan · RECRUITING
Centrum Medyczne HCP Szpital im. Jana Pawla II, Poznan, Greater Poland Voivodeship, Poland · RECRUITING
Uniwersyteckie Centrum Kliniczne w Gdansku - Smoluchowskiego 17, Gdansk, Pomeranian Voivodeship, Poland · RECRUITING
Local Institution - 4207, Iława, Warmian-Masurian Voivodeship, Poland · WITHDRAWN
Osrodek Badan Klinicznych BD Research Sp. z o.o. - Andersa 3, Iława, Warmian-Masurian Voivodeship, Poland · RECRUITING
Local Institution - 4213, Kielce, Poland · WITHDRAWN
Local Institution - 7527, Lodz, Poland · WITHDRAWN
Pro Salus Sp. z o.o.sp. k, Lodz, Poland · RECRUITING
Local Institution - 4206, Lublin, Poland · COMPLETED
Local Institution - 4216, Sochaczew, Poland · NOT_YET_RECRUITING
Local Institution - 4211, Wroclaw, Poland · COMPLETED
Local Institution - 2701, Guimarães, Braga District, Portugal · COMPLETED
Local Institution - 2704, Lisbon, Lisbon District, Portugal · COMPLETED
Local Institution - 2702, Torres Vedras, Lisbon District, Portugal · COMPLETED
Local Institution - 2703, Matosinhos Municipality, Porto District, Portugal · COMPLETED
ULS de Santa Maria,EPE - Hospital de Santa Maria - PPDS, Lisbon, Portugal · RECRUITING
Local Institution - 2706, Lisbon, Portugal · WITHDRAWN
Local Institution - 1303, Bayamón, Puerto Rico · COMPLETED
Local Institution - 1301, Bayamón, Puerto Rico · COMPLETED
Instituto De Neurologia Dra. Ivonne Fraga,Psc, San Juan, Puerto Rico · RECRUITING
Local Institution - 1304, San Juan, Puerto Rico · ACTIVE_NOT_RECRUITING
Local Institution - 1305, San Juan, Puerto Rico · WITHDRAWN
CMI Dr. Buhas Ramocea Elena Daniela - Cabinet Medical de Psihiarie, Oradea, Bihor County, Romania · RECRUITING
Prof Dr Alexandru Obregia Clinical Psychiatric Hospital- Centrul de Sanatate Mintala, Bucharest, Romania · RECRUITING
Cai Ferate Clinical Hospital Constanta, Constanța, Romania · RECRUITING
Institutul Privat de Cercetări Melchisedec pentru Boli Autoimune, Ereditare și Rare -I.P.C.M, Craiova, Romania · RECRUITING
Local Institution - 4905, Iași, Romania · WITHDRAWN
S.C. Carpe Diem SRL, Sibiu, Romania · RECRUITING
University Clinical Center of Serbia - Dr Subotica 6 - PPDS, Belgrade, Belgrade, Serbia · RECRUITING
Clinical Hospital Center Dragisa Misovic Dedinje, Belgrade, Serbia · RECRUITING
Military Medical Academy, Belgrade, Serbia · RECRUITING
Military Medical Academy, Belgrade, Serbia · RECRUITING
Local Institution - 4312, Gornja Toponica, Serbia · ACTIVE_NOT_RECRUITING
Local Institution - 4305, Kovin, Serbia · COMPLETED
University Clinical Center Kragujevac, Kragujevac, Serbia · RECRUITING
Clinical Centre of Vojvodina, Novi Sad, Serbia · RECRUITING
Univerzitna nemocnica L Pasteura Kosice-Rastislavova 43, Košice, Košice Region, Slovakia · RECRUITING
MUDr. Beata Dupejova - Neurologicka Ambulancia s.r.o, Banská Bystrica, Slovakia · RECRUITING
KONZILIUM s.r.o, Dubnica nad Váhom, Slovakia · RECRUITING
Local Institution - 4406, Košice, Slovakia · COMPLETED
Local Institution - 4407, Pezinok, Slovakia · COMPLETED
Local Institution - 4403, Vranov nad Topľou, Slovakia · COMPLETED
Local Institution - 7214, Ansan-si, Gyeonggido, South Korea · COMPLETED
Yongin Severance Hospital, Yonsei University Health System, Yongin-si, Gyeonggido, South Korea · RECRUITING
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi, South Korea · RECRUITING
Samsung Medical Center, Seoul, Seoul Teugbyeolsi, South Korea · RECRUITING
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Seoul Teugbyeolsi, South Korea · RECRUITING
Ewha Womans University Seoul Hospital, Seoul, Seoul Teugbyeolsi, South Korea · RECRUITING
Ewha Womans University Mokdong Hospital, Seoul, Seoul Teugbyeolsi, South Korea · RECRUITING
The Catholic University of Korea, Yeouido St. Mary's Hospital, Yeongdeungpo-gu, Seoul Teugbyeolsi, South Korea · RECRUITING
Hallym University Chuncheon Sacred Heart Hospital, Gangwon-do, South Korea · RECRUITING
Gangnam Severance Hospital, Yonsei University Health System, Seoul, South Korea · RECRUITING
SMG - SNU Boramae Medical Center, Seoul, South Korea · RECRUITING
Local Institution - 1-14KMN4SY, Seoul, South Korea · NOT_YET_RECRUITING
Hanyang University Seoul Hospital, Seoul, South Korea · RECRUITING
Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda, Madrid, Spain · RECRUITING
Hospital Quironsalud Malaga, Málaga, Málaga, Spain · RECRUITING
Local Institution - 2212, Lleida, Spain · COMPLETED
Hospital Clinico San Carlos, Madrid, Spain · RECRUITING
Hospital Universitario De Salamanca, Salamanca, Spain · RECRUITING
Hospital Victoria Eugenia, Seville, Spain · RECRUITING
Hospital Universitario Rio Hortega, Valladolid, Spain · RECRUITING
Hospital Viamed Montecanal, Zaragoza, Spain · RECRUITING
Local Institution - 4702, Atakum, Samsun, Turkey (Türkiye) · COMPLETED
Hacettepe University Medical Faculty, Ankara, Turkey (Türkiye) · RECRUITING
Eskisehir Osmangazi Universitesi Tip Fakultesi Hastanesi, Eskişehir, Turkey (Türkiye) · RECRUITING
Istanbul Universitesi Istanbul Tip Fakultesi Hastanesi, Istanbul, Turkey (Türkiye) · RECRUITING
Local Institution - 4705, Izmir, Turkey (Türkiye) · COMPLETED
Local Institution - 4703, Izmir, Turkey (Türkiye) · COMPLETED
Local Institution - 8007, Lviv, Lviv Oblast, Ukraine · NOT_YET_RECRUITING
MI Vinnytsia Regional Psychoneurological Hospital n.a. acad. O.I. Yushchenko, Vinnytsia, Vinnytsia Oblast, Ukraine · RECRUITING
Local Institution - 8001, Vinnytsia, Vinnytsia Oblast, Ukraine · NOT_YET_RECRUITING
Municipal NonProfit Enterprise Khmelnytskyi Regional Psychiatric Care Facility of the Khmelnytskyi Regional Council, Khmelnytskyi, Ukraine · RECRUITING
Local Institution - 8006, Lviv, Ukraine · NOT_YET_RECRUITING
MNE Cherkasy Regional Psychiatric Hospital of Cherkasy RC, Smila, Ukraine · RECRUITING
MNE Ternopil Regional Clinical Psychoneurological Hospital of TRC, Ternopil, Ukraine · RECRUITING
Neyromed LLC - Uzhhorod, Uzhhorod, Ukraine · RECRUITING

Not medical advice. Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors. Registry data refreshed at most hourly; last update posted 2026-07-30.