iTBS in MCI and Mild AD

Summary

This study aims to examine the effects of iTBS on cognitive function in individuals with MCI or mild AD, with a secondary objective of exploring prefrontal TBS mechanisms for cognitive function and the effect of iTBS on BDNF.

Interventions

• Active rTMS · DEVICE

  iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total10 sessions

• Sham rTMS · DEVICE

  sham iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) per session, total 10 sessions

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Clinical diagnosis of MCI (overall Clinical Dementia Rating of 0.5)
* Clinical diagnosis of mild Alzheimer's Disease (overall Clinical Dementia Rating of 0.5 or 1)

Exclusion Criteria:

* History of stroke
* History of uncontrol seizure
* History of significant head trauma followed by persistent neurologic deficit or known structural brain abnormality
* Mental illness
* Drug abuse

Sites (1)

• Tri-Service General Hospital, Taipei, Other, Taiwan