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Clinical trial · NCT06850623 · RECRUITING · PHASE2

Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer

Sponsor: EXACT Therapeutics AS

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Summary

The purpose of the study is to assess the efficacy and safety of Acoustic Cluster Therapy (ACT) when given in addition to chemotherapy for treatment of Locally Advanced Pancreatic Cancer.

Interventions

  • Acoustic Cluster Therapy · COMBINATION_PRODUCT

    Drug: PS101; Device: Ultrasound

  • Modified FOLFIRINOX · DRUG

    Chemotherapy

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Not deemed suitable for primary curative surgery and have radiographic and pathological disease consistent with inoperable LAPC or borderline resectable pancreatic cancer.
* Suitable to receive treatment with mFOLFIRINOX according to the Investigator's assessment.

Exclusion Criteria:

• Any prior anti-cancer treatment for pancreatic cancer (e.g. chemotherapy, surgery, radiation). Palliative bypass procedure and bile duct stenting are allowed.

Sites (10)

  • HonorHealth Research Institute, Scottsdale, Arizona · RECRUITING
  • Stanford Cancer Center Palo Alto, Stanford, California · RECRUITING
  • Beth Israel Deaconess Medical Center - Division of Hematology/Oncology, Boston, Massachusetts · RECRUITING
  • Henry Ford Centre, Detroit, Michigan · RECRUITING
  • Sidney Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania · RECRUITING
  • Allegheny General Hospital, Pittsburgh, Pennsylvania · RECRUITING
  • Brown University Cancer Institute, Providence, Rhode Island · RECRUITING
  • CAMBRIDGE CANCER TRIALS CENTRE-Addenbrooke's Hospital, Cambridge, Cambridge, United Kingdom · RECRUITING
  • Gary Weston Centre- Imperial College Healthcare- Du Cane Road, Hammersmith, London, United Kingdom · RECRUITING
  • The Royal Marsden- Downs Road, Sutton, Surrey, United Kingdom · RECRUITING

Not medical advice. Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors. Registry data refreshed at most hourly; last update posted 2026-04-03.