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Clinical trial · NCT06940687 · ENROLLING_BY_INVITATION · NA

Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers

Sponsor: Yale University

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Summary

This study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers. Heart rate (HR), heart rate variability (HRV), and brain activity will be measured as participant-caregiver dyads listen to preferred and improvised music performed by professional musicians. Investigators will leverage various measurement techniques including, but not limited to, electroencephalography (EEG), behavioral, surveys, and physiological monitoring to study the impact of live music on anxiety in AD and inter-dyad synchrony.

Interventions

  • Pre-recorded Music Session · BEHAVIORAL

    A pre-recorded concert session

  • Live Music Session · BEHAVIORAL

    A 45-minute live music performance

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Clinical Dementia Rating 0.5 - 2
* Be a person with or caregiver to a person with a diagnosis of early Alzheimer's Disease, mild dementia, and/or mild cognitive impairment (MCI)
* Able to provide informed consent
* Willing to wear an EEG headset and heart rate monitoring devices
* Willing to possibly have small patches of body / facial hair shaved to accommodate administration of heart rate monitoring devices
* Willing to answer survey questions about topics related to the study
* Willing to be audio / video recorded

Exclusion Criteria:

* Clinical Dementia Rating \<0.5 or \> 2
* Unable to provide informed consent
* Endorsing suicidal ideation (SI), self-injurious behavior, or homicidal ideation (HI) above the threshold defined in the "Risk Reduction and Safety Plan"
* Participating in another clinical trial studying AD and/or Dementia
* Starting a new prescription medication in the last 6 months
* Prescribed Benzodiazepines on an as needed basis

Sites (2)

  • Firehouse 12 Studios, New Haven, Connecticut
  • Musical Intervention Studios, New Haven, Connecticut

Not medical advice. Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors. Registry data refreshed at most hourly; last update posted 2026-02-11.