A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

Summary

The purpose of the study is to explore the safety and effects of the study drug (PF-08046876) in people diagnosed with advanced cancer of the bladder, lung, head and neck, esophagus, or pancreas. PF-08046876 is an investigational anticancer therapy called an 'antibody drug conjugate' or 'ADC'. ADCs are anticancer drugs designed to stick to cancer cells and kill them. The study drug will be given to participants through a needle in a vein (intravenous infusion). This study includes multiple parts. In the first part of the study, there will be different groups of people receiving different doses of the study drug. The study may also test different schedules.

Interventions

• PF-08046876 · DRUG

  Intravenous administration

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* 18 years of age or older
* Advanced cancer of the bladder, lung, head and neck, esophagus, or pancreas
* Measurable disease
* ECOG Performance status 0-1
* Part 1: progression or relapse following standard treatments
* Part 2: maximum of 2 prior lines of systemic therapy in the advanced setting
* Resolution of acute effects of prior anticancer therapy to baseline or Grade 1
* Consent to submit required pre-treatment tumor tissue as medically feasible

Exclusion criteria:

* Received prior treatment with an antibody drug conjugate with a camptothecin-class payload (e.g. sacituzumab govitecan, trastuzumab deruxtecan )
* Active anorexia, nausea or vomiting, and/or signs of intestinal obstruction meeting protocol exclusion
* Pulmonary disease meeting protocol exclusion
* Other unacceptable abnormalities as defined by protocol

Sites (30)

• City of Hope National Medical Center, Duarte, California · RECRUITING
• City of Hope at Irvine Lennar, Irvine, California · RECRUITING
• Ronald Reagan UCLA Medical Center, Los Angeles, California · NOT_YET_RECRUITING
• UCLA Department of Medicine-Hematology/Oncology, Los Angeles, California · NOT_YET_RECRUITING
• Santa Monica UCLA Medical Center & Orthopaedic Hospital, Santa Monica, California · NOT_YET_RECRUITING
• UCLA Hematology/Oncology - Santa Monica, Santa Monica, California · NOT_YET_RECRUITING
• Smilow Cancer Hospital - Yale New Haven Health, New Haven, Connecticut · RECRUITING
• Yale - New Haven Hospital - Yale Cancer Center, New Haven, Connecticut · RECRUITING
• Smilow Cancer Hospital Phase 1 Unit, New Haven, Connecticut · RECRUITING
• Smilow Cancer Hospital - Trumbull, Trumbull, Connecticut · RECRUITING
• Brigham and Women's Hospital, Boston, Massachusetts · RECRUITING
• Dana-Farber Cancer Institute, Boston, Massachusetts · RECRUITING
• Dana-Farber Cancer Institute - Chestnut Hill, Newton, Massachusetts · RECRUITING
• Sarah Cannon Research Institute - Pharmacy, Nashville, Tennessee · RECRUITING
• SCRI Oncology Partners, Nashville, Tennessee · RECRUITING
• The University of Texas MD Anderson Cancer Center - Conroe, Conroe, Texas · RECRUITING
• University of Texas MD Anderson Cancer Center, Houston, Texas · RECRUITING
• The University of Texas, MD Anderson Cancer Center - West Houston, Houston, Texas · RECRUITING
• The University of Texas, MD Anderson Cancer Center - League City, League City, Texas · RECRUITING
• NEXT Oncology, San Antonio, Texas · RECRUITING
• The University of Texas, MD Anderson Cancer Center - Sugar Land, Sugar Land, Texas · RECRUITING
• Princess Margaret Cancer Centre, Toronto, Ontario, Canada · RECRUITING
• Princess Margaret Cancer Centre, Toronto, Ontario, Canada · RECRUITING
• McGill University Health Centre, Montreal, Quebec, Canada · RECRUITING
• Pan American Center for Oncology Trials, LLC, Rio Piedras, Puerto Rico · RECRUITING
• Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [barcelona], Spain · RECRUITING
• Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad de, Spain · RECRUITING
• Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain · RECRUITING
• Barts Cancer Centre at St. Bartholomew's Hospital; Queen Mary University of London, London, United Kingdom · NOT_YET_RECRUITING
• The Christie NHS Foundation Trust, Manchester, United Kingdom · RECRUITING