Physical Exercise to Prevent Mild-cognitive Impairment in Patients With Kidney Disfunctions

Summary

This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems. The study includes a clinical trial where patients will either receive standard care or follow a home-based exercise program involving walking and strength training, to see if regular physical activity can improve brain function. It also includes a large-scale analysis of data from the UK Biobank to explore blood and genetic markers, brain imaging, and lifestyle factors linked to cognitive health. The ultimate aim is to find effective, easy-to-implement strategies and early warning signs that could lead to better treatment and quality of life for people living with CKD.

Interventions

• Exercise · BEHAVIORAL

  Patients will undergo a home-based low-intensity interval multi component exercise program including aerobic and strengthening exercise

• Control (Standard treatment) · OTHER

  Patients will be treated with standard therapy based on their CKD stage

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* CKD at KDOQI stage 4-5
* concomitant MCI (MOCA - MMSE (17 \< MoCA \< 26) or (16 \< MMSE \< 24)

Exclusion Criteria:

* Absolute contraindication to exercise training (e.g. unstable angina, major amputation, severe heart failure, etc.)
* Known life expectancy \< 6-month
* Uncorrected anemia (Hb \<9 g/dl)
* Non-provision of informed consent

Sites (6)

• Assistance Publique - Hôpitaux de Paris (AP-HP), Division of Geriatry, Paris, France
• Biogem, Ariano Irpino, Italy
• Lithuanian University of Health Sciences, Kaunas, Lithuania
• University Medical Center Groningen, Department of Nephrology, Groningen, Netherlands
• Medical University of Warsaw, Department of Nephrology, Dialysis and Internal Medicine, Warsaw, Poland
• University of Zurich, Zurich, Switzerland