Alzheimer's Disease and Faecal Microbiota Transplantation -a Pilot Study

Summary

The goal of this study is to assess the feasibility and safety of faecal microbiota transplantation for Alzheimer's disease.

Interventions

• Biological: Preprocessed thawed donor FMT · BIOLOGICAL

  Biological: Preprocessed FMT solution is administered to the right side of the colon during a colonoscopy.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Alzheimer's dementia mild to moderate stage
* Presence of Alzheimer pathology core 1 biomarkers as defined by National Institute on Aging-Alzheimer's Association (NIA-AA) criteria (2024)
* Capable of giving informed consent

Exclusion Criteria:

* Contraindications for colonoscopy examination
* Contraindications for Magnetic Resonance Imaging (MRI)
* Life expectancy \< 1 year
* Clinical frailty scale 7 or more
* History of seizure disorder
* History of brain tumour or intracranial bleed
* Major psychiatric disorder such as schizophrenia, bipolar disorder, or major depressive disorder
* Alcohol or substance abuse
* Decompensated heart disease
* Malignancy
* Current use of anticoagulant treatment (dual acting oral anticoagulant or warfarin)
* Pregnant or planning pregnancy
* Colonic adenomas over 1 cm, tumours or signs of active colitis on colonoscopy
* Status after colectomy or hemicolectomy
* Inflammatory bowel disease
* Immunocompromised individual
* Receiving biological/antibody treatment

Sites (1)

• University Hospital of North Norway, Tromsø, Tromsø, Troms, Norway · RECRUITING