Ketogenic Diet to Reduce Osteoarthritis Pain in MCI

Summary

Osteoarthritis and mild cognitive impairment are common conditions that share underlying biological processes related to metabolism and inflammation. This study will examine whether a well-formulated ketogenic diet influences pain, physical function, and cognitive outcomes in adults with osteoarthritis and mild cognitive impairment. Participants will follow a supervised ketogenic dietary intervention, with assessments conducted before and after the intervention to evaluate changes in symptoms and related biological markers. The goal of this study is to better understand shared mechanisms between joint pain and cognitive health and to explore whether a ketogenic dietary approach may support symptom management in these populations.

Interventions

• Well-formulated ketogenic diet · OTHER

  This is a very low carbohydrate eating pattern that is higher in fat with adequate protein. This approach focuses on a nutrient dense, whole foods approach to a ketogenic diet and recommends 4-6 servings of non-starchy vegetables per day, 1/4 cup of berries per day, daily intake of nuts/seeds, fatty fish 2-3 times per week, and an emphasis on healthy fats like avocado, nuts, and olive oil.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* English speaking
* Diagnosis of major joint osteoarthritis
* Diagnosis of mild cognitive impairment

Exclusion Criteria:

* Diabetes that requires insulin
* Cancer requiring chemo- or radiation therapy in the last 2 years
* Cardiac event within 1 year
* Recent history of renal stones
* Diagnosis of fibromyalgia
* Already following a ketogenic diet
* Following a dietary pattern that does not allow for a ketogenic approach
* Unable to control one's diet

Sites (1)

• University of Kansas Medical Center, Fairway, Kansas