Trial0

Clinical trial · NCT07454824 · RECRUITING · NA

e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

Sponsor: Johns Hopkins University

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Summary

The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in deprescribing. The multicomponent intervention, e-Align, includes delivery of educational information through the patient portal, and a pharmacist-led intervention to align medications with patient and care partner goals and reduce use of central nervous system (CNS) potentially inappropriate medicines (PIM). This work will establish the preliminary data, methods, and partnerships to undertake a multisite embedded pragmatic clinical trial. The resulting triadic-based behavioral intervention will promote patient and care partner engagement, and foster care that aligns with patients' values, and promote improved health and well-being outcomes for people with cognitive impairment and the patient's care partners through deprescribing.

Interventions

  • e-ALIGN Patient-Portal Deprescribing · OTHER

    The intervention will consist of educational materials about deprescribing, which will be sent to the patient prior to the scheduled primary care visit.

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Patients: Age ≥65, with a diagnosis of MCI or dementia based on ICD-10 codes and ≥1 active CNS-PIM, who are active patient portal users.

Care partners:

* Family or other companions \>21 years who regularly help the patient with managing medications.

Exclusion Criteria:

* As the trial will be based in primary care, individuals residing in long term care facilities or enrolled in hospice will be excluded.

Sites (1)

  • Johns Hopkins Community Physicians, Baltimore, Maryland · RECRUITING

Not medical advice. Trial0 is a navigation service, not a medical provider. Nothing here is medical advice or a recommendation to pursue any treatment; eligibility matching is informational, based on published registry criteria, and only the trial site or treating clinician can determine actual eligibility. Decisions belong with the patient and their own doctors. Registry data refreshed at most hourly; last update posted 2026-06-16.