Mild Cognitive Impairment and Neuromodulation

Summary

This is a parallel, sham-controlled design of low-intensity focused ultrasound in patients with mild cognitive impairment (MCI). The study will evaluate safety, tolerability, and effects on cognitive function.

Interventions

• Low intensity focused ultrasound · DEVICE

  low-intensity focused ultrasound applied with a two element transducer from sonic concepts.

• Sham (No Treatment) · DEVICE

  Blocked LIFU

Published eligibility criteria

Verbatim from the registry. Only the site can decide how these apply to a specific patient.

Inclusion Criteria:

* Montreal Cognitive Assessment (MoCA) scores between 18-23 inclusive, and able to consent to their own medical care.

Exclusion Criteria:

* Claustrophobia
* MRI contraindications (pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, or other implants)
* CT contraindications (pregnancy)
* Non-AD etiology (eg. Lewy body disease, vascular dementia, alcohol/drug related damage)
* Taking anti-amyloid antibodies
* Neuromod within 6 months of the study
* History of other neurological disorder
* Hx of head injury with LOC \> 10 min
* Active alcohol or drug dependence

Sites (1)

• Fralin Biomedical Research Institute at VTC, Roanoke, Virginia